IMAGene
Epigenomic and machine learning models to predict pancreatic cancer
IMAGene
is a European Project funded under the framework of the ERA-PerMed call “Multidisciplinary research projects on personalised medicine – development of clinical support tools for personalised medicine implementation”. The consortium gathers 20 partners located in Europe with different expertise and the common aim to develop, implement and test a comprehensive Cancer Risk prediction Algorithm to predict Pancreatic Cancer in high-risk asymptomatic subjects. Nowadays pancreatic cancer has the lowest survival rate of all cancers in Europe, with no early detection strategies available.
Era PerMed
project funded in the 2021 Joint Transnational Call for Proposals (JTC 2021) co-funded by the European Commission/DG Research and Innovation
Pancreatic cancer (PC) has the lowest survival rate of all cancers in Europe, with no early detection strategies available. The IMAGene project will develop, implement and test a comprehensive Cancer Risk prediction Algorithm (CRPA) to predict PC in high-risk (HR) asymptomatic subjects.
Project Aims
Work Packages
WP1
High-risk individuals selection and development of PC risk prediction algorithm (CRPA)
WP2
Efficacy of epigenetic analysis for risk profiling and cancer screening.
WP3
Radiological screening & epigenetic analysis for early detection of cancer: feasibility
WP4
HR individuals' preferences, psycho-cognitive profiles and decisions.
WP5
Address the ethical, legal and social issues (ELSI).
WP6
Costs and utility analysis, and requisites for designing larger-scale studies.
Progress
Research team
Serena Oliveri European Institute of Oncology (Milan, Italy)
Victor Moreno Catalan Institute of Oncology / IDIBELL (Barcelona, Spain)
Tomasz Wojdacz Pomeranian Medical University (Szczecin, Poland)
Louis Buscail Centre Hospitalier Universitaire de Toulouse (Toulouse, France)
Ovidiu Balacescu The Oncology Institute 'Prof Dr. Ion Chiricuta' (Cluj-Napoca, Romania)
Tudor Ciuleanu The Oncology Institute 'Prof Dr. Ion Chiricuta' (Cluj-Napoca, Romania)
Andrada Seicean The Oncology Institute 'Prof Dr. Ion Chiricuta' (Cluj-Napoca, Romania)
Calin Cainap The Oncology Institute 'Prof Dr. Ion Chiricuta' (Cluj-Napoca, Romania)
Andrei Roman The Oncology Institute 'Prof Dr. Ion Chiricuta' (Cluj-Napoca, Romania)
Adrian Trifa The Oncology Institute 'Prof Dr. Ion Chiricuta' (Cluj-Napoca, Romania)
Loredana Balacescu The Oncology Institute 'Prof Dr. Ion Chiricuta' (Cluj-Napoca, Romania)
Pierre Cordelier Centre Hospitalier Universitaire de Toulouse (Toulouse, France)
Bonanni Bernardo European Institute of Oncology (Milan, Italy)
Ilaria Cutica European Institute of Oncology (Milan, Italy)
Gervaso Lorenzo European Institute of Oncology (Milan, Italy)
Giulia Ongaro European Institute of Oncology (Milan, Italy)
Clizia Cincidda European Institute of Oncology (Milan, Italy)
Cella Chiara Alessandra European Institute of Oncology (Milan, Italy)
Olga Taryma-Leśniak Pomeranian Medical University (Szczecin, Poland)
Mireia Obón Catalan Institute of Oncology / IDIBELL (Barcelona, Spain)
Lois Riobo Catalan Institute of Oncology / IDIBELL (Barcelona, Spain)
Anna Diez-Villanueva Catalan Institute of Oncology / IDIBELL (Barcelona, Spain)
Institutions
IEO European Institute of Oncology
PMU Pomeranian Medical University
CHUT Centre Hospitalier Universitaire de Toulouse
IOCN The Oncology Institute „Prof. Dr. Ion Chiricuţă”
IDIBELL Bellvitge Biomedical Research Institute
ICO Catalan Institute of Oncology
Funding
Era PerMEd Research Project
This project has received funding from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 779282.
National agencies that funded the project:
Fondazione Regionale per la Ricerca Biomedica (FRRB), Regione Lombardia, Italy
National Centre for Research and Development (NCBR), Poland
The French National Research Agency (ANR), France
Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI), Romania
Instituto de Salud Carlos III (ISCIII), co-funded by FEDER funds –a way to build Europe–, Spain
Scientific Foundation of the Spanish Association Against Cancer (FCAECC), Spain
